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Archiv-Übersicht     Angebot Nr. 12541

Angebotsdatum: 2. November 2017
Art der Stelle: Doktorarbeit / Diplomarbeit
Fachgebiet: Biologie > Neurobiologie
Titel des Themas: Characterization of thiol switches controlled by the glutathione-S-transferase GDAP1

Institut: Universitätsmedizin Mainz, Institut für Immunologie
Prof. Stefan Dr. Tenzer
Langenbeckstr. 1
55131 Mainz
Tel.: 06131-17-6199   Fax.:
Bundesland: Rheinland-Pfalz
Homepage: http://www.unimedizin-mainz.de/immunologie/uebersicht.html
E-Mail Kontakt: mail

Beschreibung: In the framework of the DFG Priority Program 1710 (Dynamics of thiol-based redox switches in cellular physiology) the Institute for Immunology, Core Facility for Mass Spectrometry of the University Medical Center Mainz (AG Prof. Stefan Tenzer) is hiring a

PhD Candidate (m/f) „Characterization of thiol switches controlled by the glutathione-S-transferase GDAP1“

Starting date: as soon as possible
Duration: 3 years
Salary: TV-L E13 (65%)

Your Tasks:
- method development for optimized chemical proteomics workflows
- identification of target proteins of the GST GDAP1 by quantitative chemical proteomics
- identification and characterization of the proteins contained in the GSSG-induced complex of MFN2 and GDAP1 by LC-MS
- bioinformatics analyses of GDAP1-interacting proteins to identify regulated pathways and molecular networks
- working in an interdisciplinary environment in close collaboration with other projects
of the DFG-PP1710
- participation in meetings, summer schools and training courses by the DFG-PP1710

Your ideal qualification:
- Master (M.Sc.) biology, biochemistry, chemistry, bioinformatics or equivalent education
- hands-on experience or profound knowledge of protein biochemistry
- excellent analytical and writing skills
- you are ambitious, self-motivated and have high team work capabilities
- excellent knowledge of written and spoken English
- experience with proteomics, LC-MS, data analysis and bioinformatics is a plus
- experience in scientific writing is an advantage

To apply, please send a cover letter, a CV, academic record together with a list of projects you were working in and the names of at least two references in one combined pdf to tenzer@uni-mainz.de

Univ.-Prof. Dr. Stefan Tenzer
UNIVERSITÄTSMEDIZIN der Johannes Gutenberg-Universität
Institut für Immunologie, Core Facility für Massenspektrometrie
Langenbeckstr. 1, Gebäude 708
55131 Mainz
E-mail: tenzer@uni-mainz.de
Methoden: Quantitative Proteomics
Anfangsdatum: 2. November 2017
Geschätzte Dauer: 3 years
Bezahlung: TV-L E13 65%
Papers: Thaher O, Wolf C, Dey PN, Pouya A, Wüllner V, Tenzer S, Methner A. The thiol switch C684 in Mitofusin-2 mediates redox-induced alterations of mitochondrial shape and respiration. Neurochem Int. 2017. pii: S0197-0186(17)30059-1.

Distler U, Kuharev J, Navarro P, Levin Y, Schild H, Tenzer S. Drift time-specific
collision energies enable deep-coverage data-independent acquisition proteomics.
Nat Methods. 2014 Feb;11(2):167-70

Tenzer S, Moro A, Kuharev J, Francis AC, Vidalino L, Provenzani A, Macchi P.Proteome-wide characterization of the RNA-binding protein RALY-interactome using the iBioPQ (in vivo-Biotinylation-Pulldown-Quant) approach. J Proteome Res. 2013 Jun 7;12(6):2869-84.

Distler U, Kuharev J, Navarro P, Tenzer S. Label-free quantification in ion mobility-enhanced data-independent acquisition proteomics. Nat Protoc. 2016 Apr;11(4):795-812.