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Archiv-Übersicht     Angebot Nr. 12517

Angebotsdatum: 19. Oktober 2017
Art der Stelle: Diplomarbeit
Fachgebiet: Biologie > Humangenetik
Titel des Themas: PhD Student in Epigenetics (m/f) / 3 year fixed-term contract (up to 4 years), full time

Institut: Luxembourg Institute of Health
Frau Virginie De Landsheer
1 A/B Rue Thomas Edison
1445 Luxembourg
Tel.:    Fax.:
Homepage: http://https://www.lih.lu/jobs/detail/phd-student-in-epigenetics-jt1017-12685
E-Mail Kontakt: mail

Beschreibung: Luxembourg Institute of Health is a public research organisation at the forefront of biomedical sciences. With its strong research expertise in oncology, population health, infection and immunity based on human biological samples, its research activities impact on people’s health. At the Luxembourg Institute of Health, devoted scientists investigate disease mechanisms to develop new diagnostics, innovative therapies and effective tools to implement personalised medicine. The institution is the first supplier of public health information in Luxembourg, a strong cooperation partner in local and international projects and an attractive training place for ambitious early-stage researchers.

In the context of the FNR / ANR (France) funded project “MADAM”, addressing the pathomechanisms underlying comorbid depression and diabetes, Dr Jonathan Turner, PI Immune Endocrine Epigenetics Research group, is looking to recruit a :

PhD Student in Epigenetics


Type 2 Diabetes (T2D) and depression often occur together, and there is increasing evidence that they share pathophysiological and mechanistic origins, particularly based in inflammatory cytokine-mediated innate immunity, and/or the hypothalamus-pituitary-adrenal axis.

Epigenetic processes such as DNA methylation integrate the environment and inherited traits to predispose individuals to diseases. For T2D and depression, the evidence is growing that disease loci are epigenetically regulated, and that epigenotypes may be transmitted from one generation to the next and play a significant role in disease development. This PhD Student position, in the Immune Endocrine Epigenetics Research Group, aims to unravel the mechanisms underlying the link between T2D and depression in preclinical epigenetic models of non-obese T2D. Additionally, we will identify the contribution of epigenetic factors in the emergence of anxious-depressive phenotype in diabetic subjects, and whether the anxious-depressive phenotype in diabetic subjects is reversible by strategies targeting HPA axis dysfunctions.

Key Skills, Experience and Qualifications

- Master’s degree (or equivalent) in Molecular Biology or Genetics. Prior experience in epigenetics and DNA methylation would be an advantage, but is not mandatory.
- Good communication would be necessary to deal with the different partners involved in this project at the international level, as well as for restitution of the results to partners
- Excellent time management, rigor, perseverance, scientific creativity and originality, writing skills, conciseness, sense of priority and ability to work with others.
- IT skills: Office, Outlook, Endnote if needed.
- Fluency in English is mandatory, French would be an asset.

More information about the unit can be found here : https://immuneendocrineandepigenetics.lih.lu

Researchers are supported by easy access to scientific expertise, well-equipped facilities, an active seminar program as well as the possibility for close collaborations with the university and other research institutes.

Located in Luxembourg, LIH offers the opportunity to work in a dynamic, international and multilingual environment that values personal respect and professional achievement based on the highest intellectual and ethical standards. The remuneration for this position shall be based on qualification and experience.

Applications including a cover letter and a full curriculum vitae should be sent before 30 November 2017 through our website: www.lih.lu/jobs. Ref.: VD/PHDS1017/JT/DII ALL6
Anfangsdatum: 15. Dezember 2017
Geschätzte Dauer: 3 year fixed-term contract (up to 4 years), full t