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Archiv-Übersicht     Angebot Nr. 12477

Angebotsdatum: 27. September 2017
Art der Stelle: Doktorarbeit / Diplomarbeit
Fachgebiet: Chemie > Biochemie
Titel des Themas: Membrane protein folding in crowded environment

Institut: Synthetic Membrane Systems
Prof. Alexej Kedrov
Universitätsstrasse 1
40225 Düsseldorf
Tel.: 0211 81 12314   Fax.:
Bundesland: Nordrhein-Westfalen
E-Mail Kontakt: mail

Beschreibung: Within the newly founded group in the Institute of Biochemistry, Heinrich-Heine-University Düsseldorf, we employ membrane-reconstituted systems of varying complexities to study vital biological processes downto single-molecule level. Recent developments in synthetic membranes, such as nanodiscs, SMALPs and giant vesicles, allow us to conduct a comprehensive biochemical, biophysical and structural analysis on membrane proteins and their complexes in physiologically-relevant environments. With that we are aiming to elucidate conformational dynamics and macromolecular assembly of cellular machineries dedicated to protein folding, transport, and degradation, in native-like custom-tailored lipid membranes, as well as scrutinize roles of the lipid environment in protein functioning and regulation.

Currently, we are looking for Master and PhD students to study effects of macromolecular crowding on membrane protein insertion and folding mediated by the Sec translocon. Within the project we are developing de novo protein:membrane systems, which mimic the complexity of biological membranes, and investigate the membrane protein biogenesis pathway that includes ribosome targeting to the Sec system, functional dynamics of reconstituted Sec translocons, and the protein transports/insertion reactions. The project will be further supported by collaborations with groups specialized in computational biology, single-molecule biophysics and polymer synthesis.

The applicants are expected to have an experience in (membrane) protein biochemistry, biophysics and/or mathematical modeling of biological processes. Please, send your applications, incl. CV, previous work experience and references to:

Synthetic Membrane Systems (AG Kedrov)

E-mail: SynMemSys@gmail.com

Phone: +49 211 81 12314
Anfangsdatum: 27. September 2017
Geschätzte Dauer: 3 years
Papers: Selected publications:
Kedrov et al. (2016) Structural dynamics of the YidC insertase upon membrane protein insertion. Cell Rep, 17, 2943-54.
Beckert et al. (2015) Structural basis for SRP-dependent protein targeting and elongation arrest in prokaryotes. Nat Struct Mol Biol, 20, 767-73.
Kedrov et al. (2013) Elucidating the native architecture of the YidC: Ribosome complex. J Mol Biol 425, 4112-24.
Kedrov et al. (2011) A single copy of SecYEG is sufficient for preprotein translocation. EMBO J 30, 4387-97.